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Platelet-Rich Fibrin Mesotherapy is an advanced aesthetic medicine treatment that regenerates and rejuvenates the skin. Platelet-rich fibrin is an autologous substance, which means it comes from the patient’s own blood, thereby minimizing the risk of allergic reactions and complications. It is obtained by centrifuging the blood under special conditions, allowing the separation of components and the extraction of fibrin concentrate rich in platelets, leukocytes, and growth factors. These components play a key role in skin regeneration and tissue healing. Importantly, both the blood draw and centrifugation are performed during a single visit.
The treatment involves making intradermal microinjections spaced every 5–10 mm along a wrinkle or skin fold. This results in visible papules on the skin. An alternative method we also commonly use is nappage, which involves very superficial injections that do not cause papules to form. However, this technique is used only for selected areas, not the entire face, as the amount of PRF is limited.
Perceptibility
Duration
60 min
Recovery time
2-3 days
Number of treatments in a series
2-4
Platelet-Rich Fibrin (PRF) mesotherapy is recommended for individuals with skin that is:
The treatment is suitable for both younger and more mature clients. It should always be preceded by a specialist consultation, during which a cosmetologist will assess the skin’s condition and develop a personalized treatment plan.
STEP I: Makeup Removal
STEP II: Numbing
STEP III: Lifting Mesotherapy
Platelet-rich fibrin (PRF) mesotherapy stimulates the production of collagen and elastin, enhancing the skin’s firmness and elasticity. It also accelerates healing and tissue regeneration processes. For mature skin, PRF helps improve texture, even out skin tone, and reduce the appearance of fine lines. After the treatment, the skin becomes deeply hydrated, refreshed, and visibly radiant.
Contraindications for cellular fibrin mesotherapy include active skin infections, such as herpes. The treatment is not suitable for individuals with autoimmune diseases, cancer, or blood clotting disorders. Additionally, PRF mesotherapy should not be performed on pregnant or breastfeeding women.
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Platelet-Rich Fibrin (PRF) mesotherapy is used on the face, neck, décolletage, and the delicate under-eye area.
The method of PRF application is selected based on the patient’s skin needs and the desired outcome.
Absolutely! However, it’s important to consult with a specialist who can recommend the most suitable combination for your skin. PRF mesotherapy is most commonly combined with other mesotherapy treatments, such as platelet-rich plasma (PRP) or CO₂ laser therapy, to enhance regeneration and achieve more comprehensive results.
Platelet-rich fibrin mesotherapy differs from platelet-rich plasma mesotherapy primarily in the method of administration. Fibrin is injected deeper due to its thicker consistency. There are also differences in the composition of the two substances. In addition to platelets, fibrin contains stem cells, which slow down the release of growth factors. As a result, the stimulation time of fibroblasts is significantly extended. Fibrin is injected into specific areas, such as under the eyes or into nasolabial folds, whereas plasma can be applied to the entire face, neck, and décolletage. PRF mesotherapy is recommended for individuals with advanced signs of aging, while PRP mesotherapy is more suitable for patients with individual fine lines.
An alternative to treatment with fibrin may be microneedle mesotherapy or a cellular stimulator. If you’re unsure, it’s best to contact our specialists, who will help determine which treatment will work best for you.
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